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. 2018 Oct 15:323:105-108.
doi: 10.1016/j.jneuroim.2018.08.004. Epub 2018 Aug 8.

CTLA-4, PD-1 and TIM-3 expression predominantly downregulated in MS patients

Adel Mohammadzadeh  1 , Isa Abdi Rad  2 , Babak Ahmadi-Salmasi  3
Affiliations

CTLA-4, PD-1 and TIM-3 expression predominantly downregulated in MS patients

Adel Mohammadzadeh et al. J Neuroimmunol. .

Abstract

Multiple sclerosis (MS), is an autoimmune disorder of central nervous system (CNS) characterized by inflammation and demyelination. Self-tolerance impairment is considered to be induced by a combination of inherited susceptibility and environmental agents. In this work, we demonstrate that a reduction in the comparative expression of well-known inhibitory receptors (i.e., CTLA-4, PD-1, and TIM-3) is importantly linked with MS patients compared to healthy controls. The relative expression of interested genes was performed on peripheral blood mononuclear cells (PBMCs), by using quantitative real time-PCR (qRT-PCR). Our data highlighted the role of inhibitory receptors in the maintenance of immune homeostasis in autoimmune disease.

Keywords: CTLA-4; Multiple sclerosis; PD-1; TIM-3.

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