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. 2018 Oct 15:323:49-52.
doi: 10.1016/j.jneuroim.2018.07.007. Epub 2018 Jul 21.

High levels of antibodies against PtpA and PknG secreted by Mycobacterium avium ssp. paratuberculosis are present in neuromyelitis optica spectrum disorder and multiple sclerosis patients

Yael N Slavin  1 , Marco Bo  2 , Elisa Caggiu  2 , GianPietro Sechi  3 , Giannina Arru  3 , Horacio Bach  4 , Leonardo A Sechi  5
Affiliations

High levels of antibodies against PtpA and PknG secreted by Mycobacterium avium ssp. paratuberculosis are present in neuromyelitis optica spectrum disorder and multiple sclerosis patients

Yael N Slavin et al. J Neuroimmunol. .

Abstract

Mycobacterium avium ssp. paratuberculosis (Map) is the etiological agent of Paratuberculosis in ruminants. Protein tyrosine phosphatase A (PtpA) and protein kinase G (PknG) are secreted proteins necessary for the survival of the pathogen within macrophages. In this study we analyzed if Map was able to grow within astrocytes and investigated on the presence of antibodies against PtpA and PknG proteins in MS and NMOSD patients by ELISA. Map was unable to proliferate in astrocytes after of 72 h post-infection, but we observed a high level of antibodies against both virulence factors, suggesting that these patients have been exposed/infected with Map.

Keywords: Astrocyte; Multiple sclerosis; Mycobacterium avium ssp. paratuberculosis; Neuromyelitis optica spectrum disorder; Signal transduction; Virulence factors.

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