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Review
. 2018 Aug;16(8):561-571.
doi: 10.1016/S1875-5364(18)30093-1.

Application of alkaloids in reversing multidrug resistance in human cancers

Meng Wang  1 , Ze-Fa Liu  2 , Hua Tang  2 , Bao-An Chen  3
Affiliations
Review

Application of alkaloids in reversing multidrug resistance in human cancers

Meng Wang et al. Chin J Nat Med. 2018 Aug.

Abstract

Multidrug resistance (MDR) in human cancer is one of greatest challenges in cancer therapy. Natural products, especially the alkaloids, exert reversed effects on MDR with low toxicity, by interacting with various targets. In this review article, we summarize the recent progress made in the research of the main alkaloids, including classification, function, mechanism, research status, and application in reversing MDR.

Keywords: Alkaloids; Cancer; Multidrug resistance.

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