Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
- PMID: 30197301
- PMCID: PMC6326845
- DOI: 10.1016/j.cmet.2018.08.011
Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
Abstract
The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and single-meal feeding (MF), which accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability.
Keywords: aging; caloric restriction; diet composition; dietary restriction; fasting; lifespan extension; longevity; time-restricted feeding.
Published by Elsevier Inc.
Conflict of interest statement
DECLARATION of INTERESTS
The authors declare no competing interests.
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Comment in
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Exploring the effect of diet composition in calorie restriction interventions.Nat Rev Endocrinol. 2018 Nov;14(11):625. doi: 10.1038/s41574-018-0103-4. Nat Rev Endocrinol. 2018. PMID: 30258090 No abstract available.
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