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Review
. 2018 Sep;97(36):e12192.
doi: 10.1097/MD.0000000000012192.

The association between urinary tract infection during pregnancy and preeclampsia: A meta-analysis

Ling Yan  1 , Yu Jin, Hongdong Hang, Bin Yan
Affiliations
Review

The association between urinary tract infection during pregnancy and preeclampsia: A meta-analysis

Ling Yan et al. Medicine (Baltimore). 2018 Sep.

Abstract

Objective: The association between urinary tract infection (UTI) during pregnancy and preeclampsia (PE) continues to be the subject of debate. This meta-analysis aimed to examine the relationship between UTI during pregnancy and PE.

Study design: Observational studies up to October 2017, extracted from Medline, PubMed, Cochrane Library, and Embase databases, were included in the analysis. Data were extracted to 4-fold table, and the pooled odds ratio (OR) and 95% confidence intervals (CIs) of respective studies were calculated. Then meta-analysis was performed.

Results: Nineteen studies qualified the inclusion criteria. Urinary tract infection during pregnancy was found to be a risk factor for the development of PE (OR: 1.31, 95% CI: 1.22-1.40).

Conclusion: Occurrence of UTI during pregnancy increases the risk of PE in pregnant women. Screening for, and treatment of UTI should be part of routine antenatal care, especially in developing countries.

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Conflict of interest statement

The authors declare that they have no financial disclosure/conflict of interest.

Figures

Figure 1
Figure 1
Schema for study-selection for the meta-analysis (Supplementary material;). The literature search yielded 754 citations, and a total of 19 studies were included in our study.
Figure 2
Figure 2
Forest plots for overall results and heterogeneity test of the meta-analysis. The pooled odds ratio (OR) was 1.31 (95% CI: 1.22–1.40), which indicates urinary tract infection (UTI) during pregnancy as a risk factor for development of preeclampsia. And there was a low heterogeneity among the studies (P = .055 and I2 = 36.8%). CI = confidence interval.
Figure 3
Figure 3
Sensitivity analysis of the meta-analysis. Sensitivity analysis revealed that exclusion of any 1 study had little influence on the pooled odds ratio (OR; 95% CI). CI = confidence interval.
See this image and copyright information in PMC

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