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. 2018 Sep 1;15(9):1905.
doi: 10.3390/ijerph15091905.

Seroprevalence of Markers of Hepatitis B Virus Infection, Associated Factors, and Vaccination Status in Young Adults in Arkhangelsk, Northwest Russia: A Population-Based Cross-Sectional Study

Tatiana Balaeva  1   2   3 , Andrej M Grjibovski  4   5   6   7 , Olga Samodova  8 , Anatoly Sannikov  9 , Elise Klouman  10
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Seroprevalence of Markers of Hepatitis B Virus Infection, Associated Factors, and Vaccination Status in Young Adults in Arkhangelsk, Northwest Russia: A Population-Based Cross-Sectional Study

Tatiana Balaeva et al. Int J Environ Res Public Health. .

Abstract

Russia had a high incidence of hepatitis B virus (HBV) infection before the vaccination campaigns of 1997, 2001, 2007, which targeted newborns, adolescents, and adults, respectively. The aim of our study was to assess the prevalence of serological markers of HBV infection, associated factors, and vaccination status among young adults in Arkhangelsk, Northwest Russia. In this cross-sectional, population-based study, we used a quota sampling method to recruit 1243 adults aged 18⁻39 years. Participants completed a self-administrated questionnaire and were tested for hepatitis B markers. Associations between positivity for markers and selected sociodemographic and behavioral factors were studied by logistic regression. 10.9% of our participants were positive for at least one marker of hepatitis B, 1.2% were positive for HBsAg, and 42.1% were negative for all markers. In multivariable logistic regression analyses, age 30⁻34 years; lack of self-reported vaccination; and having ≥2 sexual partners in the last 6 months were associated with positivity for markers of hepatitis B. Hepatitis B vaccination was confirmed in 46.9% of participants. Although half of our study sample was vaccinated, four in 10 were still susceptible to infection and more than one participant in 100 showed evidence of an active infection.

Keywords: Russia; hepatitis B prevalence; hepatitis B vaccination; population-based study.

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Conflict of interest statement

The authors declare no conflict of interest. Due to Russian legal regulation, the study data cannot be made available for public use. However, anonymized original data can be provided on request to experts if there are questions about statistical analyses. Public availability of the data was not among the issues that were cleared with the ethical committee at Northern State Medical University in Arkhangelsk. The authors are not authorized to make the data freely available because there is no informed consent for this from the participants (Federal Law No. 149-FZ on Information, Information Technologies and Data Protection 2006 (Data Protection Act)).

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