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Meta-Analysis
. 2018 Sep 10;15(1):139.
doi: 10.1186/s12985-018-1050-3.

Lamivudine plus tenofovir combination therapy versus lamivudine monotherapy for HBV/HIV coinfection: a meta-analysis

Aoran Luo  1 , Xiaoyan Jiang  1 , Hong Ren  2
Affiliations
Meta-Analysis

Lamivudine plus tenofovir combination therapy versus lamivudine monotherapy for HBV/HIV coinfection: a meta-analysis

Aoran Luo et al. Virol J. .

Abstract

Background: Currently, there is no consensus on the efficacy and safety of lamivudine (LAM) plus tenofovir disoproxil fumarate (TDF) combination therapy versus lamivudine monotherapy in HBV/HIV coinfected patients.

Methods: A comprehensive literature search was performed in English and Chinese databases. Both relevant dichotomous and continuous variables were extracted, and the combined outcomes were expressed as a risk ratio (RR) or a standard mean difference (SMD).

Results: Eleven eligible studies were included in our analysis. For HBV-relevant outcomes, the proportion of patients with undetectable HBV, the rates of serum alanine aminotransferase (ALT) normalization and hepatitis B e antigen (HBeAg) loss were higher in the combination therapy group than the monotherapy group (RR = 1.42, 95% CI: 1.14-1.76, P = 0.002; RR = 1.36, 95% CI: 1.17-1.58, P < 0.0001; RR = 2.74, 95% CI: 1.20-6.22, P = 0.02). In addition, the rate of HIV RNA-negative conversion was higher in the combination therapy group than the monotherapy group (RR = 1.26, 95% CI: 1.11-1.42, P = 0.0003).

Conclusion: LAM plus TDF combination therapy was more efficacious than LAM monotherapy in HBV/HIV coinfected patients. As time passes, this difference becomes more pronounced.

Keywords: HBV/HIV coinfection; Lamivudine; Tenofovir.

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Figures

Fig. 1
Fig. 1
Study selection process
Fig. 2
Fig. 2
Effect of LAM + TDF vs. LAM on HBV virologic response
Fig. 3
Fig. 3
Meta-regression of treatment duration (a), and subgroup analyses by 570 treatment duration (b)
Fig. 4
Fig. 4
Effect of LAM + TDF vs. LAM on HIV RNA Negative Conversion Rate
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