. 2018 Sep;561(7723):406-410.

doi: 10.1038/s41586-018-0517-0. Epub 2018 Sep 10.

Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

Roger D Kouyos^{1

2}, Peter Rusert³, Claus Kadelka^{3

4}, Michael Huber³, Alex Marzel^{3

4}, Hanna Ebner³, Merle Schanz³, Thomas Liechti^{3

5}, Nikolas Friedrich³, Dominique L Braun^{3

4}, Alexandra U Scherrer^{3

4}, Jacqueline Weber³, Therese Uhr³, Nicolas S Baumann³, Christine Leemann^{3

4}, Herbert Kuster^{3

4}, Jean-Philippe Chave⁶, Matthias Cavassini⁷, Enos Bernasconi⁸, Matthias Hoffmann⁹, Alexandra Calmy¹⁰, Manuel Battegay¹¹, Andri Rauch¹², Sabine Yerly¹³, Vincent Aubert¹⁴, Thomas Klimkait¹⁵, Jürg Böni³, Karin J Metzner^{3

4}, Huldrych F Günthard^{16

17}, Alexandra Trkola¹⁸; Swiss HIV Cohort Study

Collaborators, Affiliations

Collaborators

Swiss HIV Cohort Study:
Alexia Anagnostopoulos, Manuel Battegay, Enos Bernasconi, Jürg Böni, Dominique L Braun, Heiner C Bucher, Alexandra Calmy, Matthias Cavassini, Angela Ciuffi, Günter Dollenmaier, Matthias Egger, Luigia Elzi, Jan Fehr, Jacques Fellay, Hansjakob Furrer, Christoph A Fux, Huldrych F Günthard, David Haerry, Barbara Hasse, Hans H Hirsch, Matthias Hoffmann, Irene Hösli, Michael Huber, Christian Kahlert, Laurent Kaiser, Olivia Keiser, Thomas Klimkait, Roger D Kouyos, Helen Kovari, Bruno Ledergerber, Gladys Martinetti, Begona Martinez de Tejada, Catia Marzolini, Karin J Metzner, Nicolas Müller, Dunja Nicca, Paolo Paioni, Guiseppe Pantaleo, Matthieu Perreau, Andri Rauch, Christoph Rudin, Alexandra U Scherrer, Patrick Schmid, Roberto Speck, Marcel Stöckle, Philip Tarr, Alexandra Trkola, Pietro Vernazza, Gilles Wandeler, Rainer Weber, Sabine Yerly

Affiliations

¹ Institute of Medical Virology, University of Zurich, Zurich, Switzerland. roger.kouyos@usz.ch.
² Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. roger.kouyos@usz.ch.
³ Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
⁴ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁵ ImmunoTechnology Section, Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, USA.
⁶ Clinique de La Source, Lausanne, Switzerland.
⁷ Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
⁸ Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
⁹ Division of Infectious Diseases, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
¹⁰ Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
¹¹ Division of Infectious Diseases, University Hospital Basel, University of Basel, Basel, Switzerland.
¹² Department of Infectious Diseases, University Hospital Bern, University of Bern, Bern, Switzerland.
¹³ Laboratory of Virology, Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
¹⁴ Division of Immunology and Allergy, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
¹⁵ Division of Infection Diagnostics, Department of Biomedicine-Petersplatz, University of Basel, Basel, Switzerland.
¹⁶ Institute of Medical Virology, University of Zurich, Zurich, Switzerland. huldrych.guenthard@usz.ch.
¹⁷ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. huldrych.guenthard@usz.ch.
¹⁸ Institute of Medical Virology, University of Zurich, Zurich, Switzerland. trkola.alexandra@virology.uzh.ch.

PMID: 30202088
DOI: 10.1038/s41586-018-0517-0

Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

Roger D Kouyos et al. Nature. 2018 Sep.

. 2018 Sep;561(7723):406-410.

doi: 10.1038/s41586-018-0517-0. Epub 2018 Sep 10.

Authors

Collaborators

Swiss HIV Cohort Study:
Alexia Anagnostopoulos, Manuel Battegay, Enos Bernasconi, Jürg Böni, Dominique L Braun, Heiner C Bucher, Alexandra Calmy, Matthias Cavassini, Angela Ciuffi, Günter Dollenmaier, Matthias Egger, Luigia Elzi, Jan Fehr, Jacques Fellay, Hansjakob Furrer, Christoph A Fux, Huldrych F Günthard, David Haerry, Barbara Hasse, Hans H Hirsch, Matthias Hoffmann, Irene Hösli, Michael Huber, Christian Kahlert, Laurent Kaiser, Olivia Keiser, Thomas Klimkait, Roger D Kouyos, Helen Kovari, Bruno Ledergerber, Gladys Martinetti, Begona Martinez de Tejada, Catia Marzolini, Karin J Metzner, Nicolas Müller, Dunja Nicca, Paolo Paioni, Guiseppe Pantaleo, Matthieu Perreau, Andri Rauch, Christoph Rudin, Alexandra U Scherrer, Patrick Schmid, Roberto Speck, Marcel Stöckle, Philip Tarr, Alexandra Trkola, Pietro Vernazza, Gilles Wandeler, Rainer Weber, Sabine Yerly

Affiliations

¹ Institute of Medical Virology, University of Zurich, Zurich, Switzerland. roger.kouyos@usz.ch.
² Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. roger.kouyos@usz.ch.
³ Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
⁴ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁵ ImmunoTechnology Section, Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, USA.
⁶ Clinique de La Source, Lausanne, Switzerland.
⁷ Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
⁸ Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
⁹ Division of Infectious Diseases, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
¹⁰ Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
¹¹ Division of Infectious Diseases, University Hospital Basel, University of Basel, Basel, Switzerland.
¹² Department of Infectious Diseases, University Hospital Bern, University of Bern, Bern, Switzerland.
¹³ Laboratory of Virology, Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
¹⁴ Division of Immunology and Allergy, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
¹⁵ Division of Infection Diagnostics, Department of Biomedicine-Petersplatz, University of Basel, Basel, Switzerland.
¹⁶ Institute of Medical Virology, University of Zurich, Zurich, Switzerland. huldrych.guenthard@usz.ch.
¹⁷ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. huldrych.guenthard@usz.ch.
¹⁸ Institute of Medical Virology, University of Zurich, Zurich, Switzerland. trkola.alexandra@virology.uzh.ch.

PMID: 30202088
DOI: 10.1038/s41586-018-0517-0

Abstract

Understanding the determinants of broadly neutralizing antibody (bNAb) evolution is crucial for the development of bNAb-based HIV vaccines¹. Despite emerging information on cofactors that promote bNAb evolution in natural HIV-1 infections, in which the induction of bNAbs is genuinely rare², information on the impact of the infecting virus strain on determining the breadth and specificity of the antibody responses to HIV-1 is lacking. Here we analyse the influence of viral antigens in shaping antibody responses in humans. We call the ability of a virus strain to induce similar antibody responses across different hosts its antibody-imprinting capacity, which from an evolutionary biology perspective corresponds to the viral heritability of the antibody responses. Analysis of 53 measured parameters of HIV-1-binding and neutralizing antibody responses in a cohort of 303 HIV-1 transmission pairs (individuals who harboured highly related HIV-1 strains and were putative direct transmission partners or members of an HIV-1 transmission chain) revealed that the effect of the infecting virus on the outcome of the bNAb response is moderate in magnitude but highly significant. We introduce the concept of bNAb-imprinting viruses and provide evidence for the existence of such viruses in a systematic screening of our cohort. The bNAb-imprinting capacity can be substantial, as indicated by a transmission pair with highly similar HIV-1 antibody responses and strong bNAb activity. Identification of viruses that have bNAb-imprinting capacities and their characterization may thus provide the potential to develop lead immunogens.

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HIV-1's fingerprint.
Hofer U. Hofer U. Nat Rev Microbiol. 2018 Nov;16(11):658-659. doi: 10.1038/s41579-018-0086-0. Nat Rev Microbiol. 2018. PMID: 30214022 No abstract available.

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Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

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