Review
doi: 10.1177/1559827616629117.
eCollection 2016 May-Jun.
Nutritional Immunity: Starving Pathogens of Trace Minerals
Affiliations
- PMID: 30202269
- PMCID: PMC6124953
- DOI: 10.1177/1559827616629117
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Review
Nutritional Immunity: Starving Pathogens of Trace Minerals
Am J Lifestyle Med.
.
Abstract
Nutritional immunity is a process by which a host organism sequesters trace minerals in an effort to limit pathogenicity during infection. Circulating concentrations of minerals, such as iron and zinc, decline rapidly and dramatically with the inflammation associated with infection. The decline in iron and zinc is thought to starve invading pathogens of these essential elements, limiting disease progression and severity. The mechanisms contributing to the hypoferremia and hypozincemia of inflammation and potential interventions that exploit this process for the management of infection will be discussed.
Keywords: hepcidin; infection; inflammation; iron; zinc.
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References
-
- Schade AL, Caroline L. Raw hen egg white and the role of iron in growth inhibition of Shigella dysenteriae, Staphylococcus aureus, Escherichia coli and Saccharomyces cerevisiae. Science. 1944;100:14-15. - PubMed
-
- Schade AL, Caroline L. An iron-binding component in human blood plasma. Science. 1946;104:340. - PubMed
-
- Weinberg ED. Nutritional immunity. Host’s attempt to withhold iron from microbial invaders. JAMA. 1975;231:39-41. - PubMed
-
- Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005;106:1864-1866. - PubMed
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