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. 2018 Sep 8:15:21.
doi: 10.1186/s12979-018-0126-7. eCollection 2018.

The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population

Ying Tang #  1   2 , Peifen Liang #  1   2 , Junzhe Chen #  1   2 , Sha Fu  1   2 , Bo Liu  1   2 , Min Feng  1   2 , Baojuan Lin  1   2 , Ben Lee  3 , Anping Xu  1   2 , Hui Y Lan  4   5
Affiliations

The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population

Ying Tang et al. Immun Ageing. .

Abstract

Background: Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study.

Methods: Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45.9 years) who received routine physical examination at Sun Yat-sen Memorial Hospital, Guangzhou, China.

Results: In total of 6060 healthy people, serum levels of hs-CRP were significantly increased with ageing (P < 0.05), particularly in those with age over 45-year-old (1.31[0.69-2.75] vs 1.05[0.53-2.16]mg/L, P < 0.001). Interestingly, levels of serum hs-CRP were significantly higher in male than female population (1.24[0.65-2.57] vs 1.07[0.53-2.29]mg/L, P < 0.001). Correlation analysis also revealed that serum levels of hs-CRP positively correlated with age and SUA, but inversely correlated with serum levels of HDL-c and SOD (all P < 0.05).

Conclusions: Baseline levels of serum hs-CRP are increased with ageing and are significantly higher in male than female healthy population. In addition, elevated serum levels of hs-CRP are also associated with increased SUA but decreased HDL-c and SOD. Thus, serum levels of hs-CRP may be an indicator associated with ageing in healthy Chinese population.

Keywords: Ageing; Hs-CRP; Inflammation; Risk factor.

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Conflict of interest statement

The institutional Review Boards of Sun Yat-sen Memorial Hospital approved this study and waived the need for informed consent.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
hs-CRP levels in different age groups. Each bar represents the median and 95%CI as indicated. *p < 0.05, ***p < 0.001 compared to the age subgroup of 18–30 year-old population
Fig. 2
Fig. 2
Scatter plot with linear regression line showing the correlations between hs-CRP and age (a), SOD (b), HDL-C (c) and SUA (d) in male
Fig. 3
Fig. 3
Scatter plot with linear regression line showing the correlations between hs-CRP and age (a), SOD (b), HDL-C (c) and SUA (d) in female
See this image and copyright information in PMC

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