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. 1986 Sep;323(6085):226-32.
doi: 10.1038/323226a0.

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

Y Yarden, J A Escobedo, W J Kuang, T L Yang-Feng, T O Daniel, P M Tremble, E Y Chen, M E Ando, R N Harkins, U Francke, et al.

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

Y Yarden et al. Nature. 1986 Sep.

Abstract

The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5.

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