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. 1986 Aug 22;8(4):209-22.
doi: 10.1007/BF01957781.

The beta-adrenoceptor-adenylate cyclase complex. From model to biochemical reality

A P Ijzerman, H Timmerman

The beta-adrenoceptor-adenylate cyclase complex. From model to biochemical reality

A P Ijzerman et al. Pharm Weekbl Sci. .

Abstract

Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.

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