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Review
. 2018 Sep 11;16(1):184.
doi: 10.1186/s12957-018-1488-1.

Intraoperative ultrasound in breast cancer surgery-from localization of non-palpable tumors to objectively measurable excision

Natasa Colakovic  1 , Darko Zdravkovic  2 , Zlatko Skuric  3 , Davor Mrda  4 , Jasna Gacic  2 , Nebojsa Ivanovic  2
Affiliations
Review

Intraoperative ultrasound in breast cancer surgery-from localization of non-palpable tumors to objectively measurable excision

Natasa Colakovic et al. World J Surg Oncol. .

Abstract

Background: The utilization of intraoperative ultrasound (IOUS) in breast cancer surgery is a relatively new concept in surgical oncology. Over the last few decades, the field of breast cancer surgery has been striving for a more rational approach, directing its efforts towards removing the tumor entirely yet sparing tissue and structures not infiltrated by tumor cells. Further progress in objectivity and optimization of breast cancer excision is possible if we make the tumor and surrounding tissue visible and measurable in real time, during the course of the operation; IOUS seems to be the optimal solution to this complex requirement. IOUS was introduced into clinical practice as a device for visualization of non-palpable tumors, and compared to wire-guided localization (WGL), IOUS was always at least a viable, or much better alternative, in terms of both precision in identification and resection and for patients' and surgeons' comfort. In recent years, intraoperative ultrasound has been used in the surgery of palpable tumors to optimize resection procedures and overcome the disadvantages of classic palpation guided surgery.

Objective: The aim of this review is to show the role of IOUS in contemporary breast cancer surgery and its changes over time.

Methods: A PubMed database comprehensive search was conducted to identify all relevant articles according to assigned key words.

Conclusion: Over time, the use of IOUS has been transformed from being the means of localizing non-palpable lesions to an instrument yielding a reduced number of positive resection margins, with a smaller volume of healthy breast tissue excided around tumor, by making the excision of the tumor optimal and objectively measurable.

Keywords: Breast cancer excision; Intraoperative ultrasound; Tumor localization.

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Not applicable.

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The manuscript has not been published previously, in any language, in whole or in part, and is not currently under consideration elsewhere.

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The authors declare that they have no competing interests.

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References

    1. Schwartz GF, Goldberg BB, Rifkin MD, D'Orazio SE. Ultrasonography: an alternative to X-ray-guided needle localization of nonpalpable breast masses. Surgery. 1988;104:870–873. - PubMed
    1. Rahusen FD, Taets van Amerongen AH, van Diest PJ, Borgstein PJ, Bleichrodt RP, Meijer S. Ultrasound-guided lumpectomy of nonpalpable breast cancers: a feasibility study looking at the accuracy of obtained margins. J Surg Oncol. 1999;72:72–76. doi: 10.1002/(SICI)1096-9098(199910)72:2<72::AID-JSO6>3.0.CO;2-M. - DOI - PubMed
    1. Snider H, Morrison D. Intraoperative ultrasound localization of nonpalpable breast lesions. Ann Surg Oncol. 1999;6:308–314. doi: 10.1007/s10434-999-0308-9. - DOI - PubMed
    1. Smith LF, Rubio IT, Henry-Tillman R, Korourian S, Klimberg VS. Intraoperative ultrasound-guided breast biopsy. Am J Surg. 2000;180:419–423. doi: 10.1016/S0002-9610(00)00500-6. - DOI - PubMed
    1. Rahusen FD, Bremers AJ, Fabry HF, van Amerongen AH, BOOm RP, Meijer S, et al. Ultrasound-guided lumpectomy of nonpalpable breast cancer versus wire-guided resection: a randomized clinical trial. Ann Surg Oncol. 2002;9:994–998. doi: 10.1007/BF02574518. - DOI - PubMed