doi: 10.1016/0262-1746(86)90187-3.
Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures
- PMID: 3020587
- DOI: 10.1016/0262-1746(86)90187-3
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Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures
Prostaglandins Leukot Med.
1986 Aug.
Abstract
Interleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin. Depletion of the T8+ suppressor cell subset of human T cells resulted in enhanced lymphokine production and further augmentation by LTB4. These findings suggest that LTB4 can regulate immune responses through its modulation of lymphokine production.
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