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. 1986 Aug;23(2-3):207-10.
doi: 10.1016/0262-1746(86)90187-3.

Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures

M Rola-Pleszczynski, P A Chavaillaz, I Lemaire

Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures

M Rola-Pleszczynski et al. Prostaglandins Leukot Med. 1986 Aug.

Abstract

Interleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin. Depletion of the T8+ suppressor cell subset of human T cells resulted in enhanced lymphokine production and further augmentation by LTB4. These findings suggest that LTB4 can regulate immune responses through its modulation of lymphokine production.

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