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. 2018 Aug;35(4):344-350.
doi: 10.5114/ada.2018.75609. Epub 2018 Aug 21.

Decreased blood CD4+PD-1+ and CD8+PD-1+ T cells in psoriatic patients with and without arthritis

Joanna Bartosińska  1 , Ewelina Zakrzewska  2 , Joanna Purkot  2 , Anna Michalak-Stoma  1 , Małgorzata Kowal  1 , Dorota Krasowska  1 , Grażyna Chodorowska  1 , Krzysztof Giannopoulos  2
Affiliations

Decreased blood CD4+PD-1+ and CD8+PD-1+ T cells in psoriatic patients with and without arthritis

Joanna Bartosińska et al. Postepy Dermatol Alergol. 2018 Aug.

Abstract

Introduction: Psoriasis with and without arthritis have common immunological mechanisms which among others involve the interactions between cytokines produced by T cells, including Th1, Th17 and Th22. Although quite a lot is known about psoriasis pathogenesis, the cause of chronic immune activation and response in the disease remains unclear. One of the negative regulators of the immune system is programmed death 1 (PD-1).

Aim: To assess the expression level of PD-1 in the peripheral T cells of psoriatic patients with and without arthritis.

Material and methods: The study included 23 psoriatic patients with arthritis, 52 psoriatic patients without arthritis and 52 healthy controls. The percentages of CD3+, CD4+, CD8+, CD4+PD-1+ and CD8+PD-1+ T cells were analyzed using flow cytometry.

Results: The percentages of CD4+PD-1+ as well as CD8+PD-1+ T cells in the psoriatic patients both with and without arthritis were significantly lower than in the control group. The percentages of CD4+PD-1+ as well as CD8+PD-1+T cells were not significantly different between the psoriatic patients with and without arthritis. A significant positive correlation between PD-1 expression on the CD4+ and CD8+ T cells was found in the psoriatic patients without arthritis.

Conclusions: Impairment of the negative co-stimulation from PD-1 may be another common characteristic of psoriasis both with and without arthritis.

Keywords: programmed death 1; psoriasis; psoriatic arthritis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Representative flow cytometry analysis of PD-1 expression on CD4+ (A–C) and CD8+ (D–F) T cells from psoriatic patients without arthritis (A, D), with arthritis (B, E) and healthy controls (C, F)
Figure 2
Figure 2
Correlation between CD4+PD-1 and CD8+PD-1 for psoriatic patients without (A) and with (B) arthritis
See this image and copyright information in PMC

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