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. 2018 Apr-Jun;62(2):138-143.

Peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy

Muhammed Şahin  1 , Alparslan Şahin  2 , Fatih Mehmet Türkcü  3 , Hamza Aslanhan  4 , Harun Yüksel  5
Affiliations

Peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy

Muhammed Şahin et al. Rom J Ophthalmol. 2018 Apr-Jun.

Abstract

Objective: We aimed to investigate the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell complex (mGCC) thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy (crNAION) analyzed by spectral domain optical coherence tomography (SD-OCT). Methods: Patients with crNAION, and healthy control subjects were enrolled in the study. All participants underwent SD-OCT for measurement of pRNFL, mGCC, and central macular thickness (CMT). The measurements of the eyes of the patients with crNAION were compared with those of the control subjects and unaffected fellow eyes. Results: A total of 25 patients with crNAION were eligible for the study. The control group consisted of 50 healthy subjects. The pRNFL and mGCC thickness in eyes with crNAION were found to be significantly thinner in all quadrants when compared to those of healthy control subjects and unaffected fellow eyes. The CMT of the eyes with crNAION was similar to that of the healthy control subjects. Conclusions: We demonstrated that mGCC and pRNFL thickness measurement by SD-OCT are capable of detecting axonal damage in eyes with crNAION. Furthermore, this study used SD-OCT and found that mGCC and pRNFL had the ability to detect GC loss in the eyes of the patients with crNAION.

Keywords: central macular thickness; macular ganglion cell complex; nonarteritic anterior ischemic optic neuropathy; peripapillary retinal nerve fiber layer.

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Figures

Fig. 1
Fig. 1
Representative OCT image of the nine ETDRS subfield C = central, SIM = superior inner quadrant in the macula, NIM = nasal inner quadrant, IIM = inferior inner quadrant, TIM = temporal inner quadrant, SOM = superior outer quadrant in the macula, NOM = nasal outer quadrant, IOM = inferior outer quadrant, TOM = temporal outer quadrant
Fig. 2
Fig. 2
pRNFL in chronic NAION and unaffected fellow eye and control group pRNFL(a) = average, (in) = inferonasal, (sn) = superonasal, (n) = nasal, (st) = superotemporal, (t) = temporal
Fig. 3
Fig. 3
mGCC in chronic phase of NAION and unaffected fellow eye and control group SIM = superior inner quadrant in the macula, NIM = nasal inner quadrant, IIM = inferior inner quadrant, TIM = temporal inner quadrant, SOM = superior outer quadrant in the macula, NOM = nasal outer quadrant, IOM = inferior outer quadrant, TOM = temporal outer quadrant
See this image and copyright information in PMC

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References

    1. Hayreh SS, Joos KM, Podhajsky PA, Long CR. Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1994;118(6):766–780. - PubMed
    1. Nagy V, Steiber Z, Takacs L, Vereb G, Berta A, Bereczky Z, Pfliegler G. Trombophilic screening for nonarteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol. 2006;244(1):3–8. - PubMed
    1. Hayreh SS. Anterior ischaemic optic neuropathy. I. Terminology and pathogenesis. Br J Ophthalmol. 1974;58(12):955–963. - PMC - PubMed
    1. Lee MS, Grossman D, Arnold AC, Sloan FA. Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients. Ophthalmology. 2011;118(5):959–963. - PMC - PubMed
    1. Levin LA, Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol Chic Ill 1960. 1996;114(4):488–491. - PubMed

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