Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr;126(4):367-375.
doi: 10.1007/s00702-018-1925-x. Epub 2018 Sep 11.

Tyrosine-hydroxylase immunoreactivity in the mouse transparent brain and adrenal glands

David Godefroy  1   2 , William Rostène  3 , Youssef Anouar  2 , Annabelle Reaux-Le Goazigo  1
Affiliations
Review

Tyrosine-hydroxylase immunoreactivity in the mouse transparent brain and adrenal glands

David Godefroy et al. J Neural Transm (Vienna). 2019 Apr.

Erratum in

Abstract

Working on catecholamine systems for years, the neuropharmacologist Arvid Carlsson has made a number of important and pioneering discoveries, which have highlighted the key role of these neuronal and peripheral neurotransmitters in brain functions and adrenal regulations. Since then, major advances have been made concerning the distribution of the catecholaminergic systems in particular by studying their rate-limiting enzyme, tyrosine hydroxylase (TH). Recently new methods of tissue transparency coupled with in toto immununostaining and three-dimensional (3D) imaging technologies allow to precisely map TH immunoreactive pathways in the mouse brain and adrenal glands. High magnification images and movies obtained with combined technologies (iDISCO+ and light-sheet microscopy) are presented in this review dedicated to the pioneer work of Arvid Carlsson and his collaborators.

Keywords: Adrenals; Clearing; Dopamine mapping; Mouse brain; Tyrosine hydroxylase; iDISCO+.

PubMed Disclaimer

References

    1. Prog Histochem Cytochem. 2016 Aug;51(2):9-23 - PubMed
    1. Nat Protoc. 2012 Nov;7(11):1983-95 - PubMed
    1. Psychoneuroendocrinology. 2002 Jul;27(5):533-48 - PubMed
    1. Acta Physiol Scand Suppl. 1954;31(113):79-107 - PubMed
    1. Mol Brain. 2017 Jul 20;10(1):33 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources