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. 2018 Sep 26;16(37):8379-8383.
doi: 10.1039/c8ob01349g.

Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

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Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

Wei Wei et al. Org Biomol Chem. .

Abstract

A simple and facile catalyst-free method for the construction of α-thioacrylic acids has been developed from readily-available aryl alkynoates and thiols at room temperature. Various α-thioacrylic acids could be conveniently and efficiently obtained in moderate to good yields via cascade thiolation and 1,4-aryl migration of aryl alkynoates in the absence of any catalyst and additive.

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