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Review
. 2018 Aug 1;8(8):1343-1355.
eCollection 2018.

Multifaceted regulation and functions of replication factor C family in human cancers

Yanling Li  1 , Sijie Gan  1 , Lin Ren  1 , Long Yuan  1 , Junlan Liu  1 , Wei Wang  1 , Xiaoyu Wang  1 , Yi Zhang  1 , Jun Jiang  1 , Fan Zhang  1 , Xiaowei Qi  1
Affiliations
Review

Multifaceted regulation and functions of replication factor C family in human cancers

Yanling Li et al. Am J Cancer Res. .

Abstract

Replication factor C (RFC) family is a complex comprised of the RFC1, RFC2, RFC3, RFC4, and RFC5 subunits, which acts as a primer recognition factor for DNA polymerase. It is reported that RFC, biologically active in various malignant tumors, may play an important role in the proliferation, progression, invasion, and metastasis of cancer cells. It could act as an oncogene or tumor suppressor gene based on the cellular and histological characteristics of the tumor. In this review, we summarized the updated researches on the structure, physiological function, and expression pattern of RFC in a variety of tumors, the underlying mechanisms on carcinogenesis, and the potentials of RFC family members in the diagnosis and prognosis prediction.

Keywords: Replication factor C; expression; function; human cancer.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Protein sequence alignment of the five human RFC family members (DNAman). Different colors indicate the different levels of homology of the five proteins. Black denotes the highest level of homology, and pink, blue and yellow denote the decreasing levels of homology.
Figure 2
Figure 2
Mutation and copy number alterations of RFC family members across different human cancers (cBioPortal).
See this image and copyright information in PMC

References

    1. Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K, et al. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. Genomics. 1995;25:274–278. - PubMed
    1. Tsurimoto T, Stillman B. Purification of a cellular replication factor, RF-C, that is required for coordinated synthesis of leading and lagging strands during simian virus 40 DNA replication in vitro. Mol Cell Biol. 1989;9:609–619. - PMC - PubMed
    1. Zhou Y, Hingorani MM. Impact of individual proliferating cell nuclear antigen-DNA contacts on clamp loading and function on DNA. J Biol Chem. 2012;287:35370–35381. - PMC - PubMed
    1. Bowman GD, O’Donnell M, Kuriyan J. Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature. 2004;429:724–730. - PubMed
    1. Luckow B, Bunz F, Stillman B, Lichter P, Schutz G. Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans. Mol Cell Biol. 1994;14:1626–1634. - PMC - PubMed

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