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Randomized Controlled Trial
. 2018 Sep 4:20:650-654.
doi: 10.1016/j.nicl.2018.09.003. eCollection 2018.

The effect of physical exercise on cerebral blood flow in Alzheimer's disease

Lisa A van der Kleij  1 , Esben T Petersen  2 , Hartwig R Siebner  3 , Jeroen Hendrikse  1 , Kristian S Frederiksen  4 , Nanna A Sobol  5 , Steen G Hasselbalch  4 , Ellen Garde  6
Affiliations
Randomized Controlled Trial

The effect of physical exercise on cerebral blood flow in Alzheimer's disease

Lisa A van der Kleij et al. Neuroimage Clin. .

Abstract

In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.

Keywords: ACC, anterior cingulate cortex; AD, Alzheimer's disease; Alzheimer's Disease; Arterial Spin labeling; CBF, cerebral blood flow; Cerebral Blood Flow; MCI, mild cognitive impairment; MMSE, Mini Mental State Examination; MRI; PCC, posterior cingulate gyrus; Physical Exercise; Randomized Controlled Trial; SPG, superior parietal gyrus.

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Figures

Fig. 1
Fig. 1
Flowchart.
Fig. 2
Fig. 2
Change in absolute CBF value (mL/100 g/min) for whole brain, frontal regions, anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), superior parietal gyrus (SPG), and the precuneus.
See this image and copyright information in PMC

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