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Review
. 2018 Aug;6(15):291.
doi: 10.21037/atm.2018.06.34.

Hypertension genomics and cardiovascular prevention

Fu Liang Ng  1   2 , Helen R Warren  1 , Mark J Caulfield  1   2
Affiliations
Review

Hypertension genomics and cardiovascular prevention

Fu Liang Ng et al. Ann Transl Med. 2018 Aug.

Abstract

Hypertension continues to be a major risk factor for global mortality, and recent genome-wide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. In light of the new knowledge from the largest cardiovascular GWAS to date, we review the potential impact of genomics on discovering potential drug targets, risk stratification with genetic risk scores, drug selection with pharmacogenetics, and exploring insights provided by gene-environment interactions.

Keywords: Hypertension; cardiovascular disease; gene-environment; genetics; pharmacogenetics; risk score.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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