Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977;54(1-2):95-106.
doi: 10.1007/BF01314382.

The effect of cordycepin on the multiplication of Semliki Forest virus and on polyadenylation of viral RNA

R Wittek, H Koblet, A Menna, R Wyler

The effect of cordycepin on the multiplication of Semliki Forest virus and on polyadenylation of viral RNA

R Wittek et al. Arch Virol. 1977.

Abstract

Cordycepin (3'-deoxyadenosine), at a concentration of 20 microgram/ml, has a marked effect on Semliki Forest virus multiplication. The appearance of plaque forming units is delayed by about 2 hours and the yield greatly reduced. The incorporation of [3H] uridine into intracellular viral RNAs reaches less than 50 per cent of controls. However, no specific effect on poly (A) synthesis could be detected. The binding efficiency of viral RNAs on nitrocellulose membranes and poly (U) sepharose is not affected by cordycepin. The average poly (A) length of total intracellular viral RNA was calculated on the basis of the ratio of the radioactivity of adenosine-monophosphate: adenosine and found to be about 35 nucleotides in treated and untreated cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Virology. 1975 Jan;63(1):1-14 - PubMed
    1. J Virol. 1975 Dec;16(6):1575-83 - PubMed
    1. J Virol. 1976 Oct;20(1):170-6 - PubMed
    1. Appl Microbiol. 1972 Sep;24(3):323-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Dec;67(4):1878-85 - PubMed