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. 1986 Aug 29;139(1):353-60.
doi: 10.1016/s0006-291x(86)80121-8.

Interleukin 1 alpha mRNA in virus-transformed T and B cells

T Noma, T Nakamura, M Maeda, M Okada, Y Taniguchi, Y Tagaya, Y Yaoita, J Yodoi, T Honjo

Interleukin 1 alpha mRNA in virus-transformed T and B cells

T Noma et al. Biochem Biophys Res Commun. .

Abstract

IL-1 alpha cDNA clone was isolated from a T cell line infected by the human T lymphotropic retrovirus type-I (HTLV-I/ATLV). We found significant amounts of mRNA hybridizing to IL-1 alpha cDNA not only in HTLV-I-transformed T cells but also in Epstein-Barr Virus-transformed B cells. A part of IL-2 receptor inducing activity in Adult T cell leukemia (ATL) cell line seems to be due to IL-1 alpha.

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