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Review
. 2018 Sep 13;14(9):e1007200.
doi: 10.1371/journal.ppat.1007200. eCollection 2018 Sep.

It's in the mix: Reassortment of segmented viral genomes

Anice C Lowen  1
Affiliations
Review

It's in the mix: Reassortment of segmented viral genomes

Anice C Lowen. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Reassortment requires viruses to meet on multiple scales.
For reassortment to occur between viruses of two distinct genotypes, these viruses must infect the same host (A) and the same tissue within that host (B). Either the inoculating viruses or their progeny must come together within the same cell (C). Finally, the coinfecting viral genomes must mix within the coinfected cell, and replicated segments must be copackaged, processes which may be limited by compartmentalization of viral replication and selectivity of genome incorporation, respectively (D). When all of these criteria are met, progeny viruses of both reassortant and parental viral genotypes will emerge from the cell (E).
Fig 2
Fig 2. Reassortant viruses are often less fit than parental strains.
The evolutionary success of reassortant progeny viruses depends on the compatibility of the reassortant genes and the selection conditions of the host environment. Thus, even when reassortment occurs efficiently (A), the prevalence of reassortant viruses may be limited by inherently low fitness and/or competition with parental viruses present in the same host or host population (B).
See this image and copyright information in PMC

References

    1. Briese T, Calisher CH, Higgs S (2013) Viruses of the family Bunyaviridae: are all available isolates reassortants? Virology 446: 207–216. 10.1016/j.virol.2013.07.030 - DOI - PubMed
    1. McDonald SM, Matthijnssens J, McAllen JK, Hine E, Overton L, et al. (2009) Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations. PLoS Pathog 5: e1000634 10.1371/journal.ppat.1000634 - DOI - PMC - PubMed
    1. Stenglein MD, Jacobson ER, Chang LW, Sanders C, Hawkins MG, et al. (2015) Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. PLoS Pathog 11: e1004900 10.1371/journal.ppat.1004900 - DOI - PMC - PubMed
    1. Steel J, Lowen AC (2014) Influenza A virus reassortment. Curr Top Microbiol Immunol 385: 377–401. 10.1007/82_2014_395 - DOI - PubMed
    1. Hon CC, Lam TY, Drummond A, Rambaut A, Lee YF, et al. (2006) Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B. J Virol 80: 8503–8509. 10.1128/JVI.00585-06 - DOI - PMC - PubMed

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