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. 1986 Oct;394(2):267-73.
doi: 10.1016/0165-3806(86)90102-1.

Prenatal protein malnutrition affects synaptic potentiation in the dentate gyrus of rats in adulthood

K B Austin, J Bronzino, P J Morgane

Prenatal protein malnutrition affects synaptic potentiation in the dentate gyrus of rats in adulthood

K B Austin et al. Brain Res. 1986 Oct.

Abstract

Long-term potentiation (LTP) was studied in the dentate gyrus of anesthetized normal and prenatally protein malnourished rats in adulthood. LTP was initiated by high-frequency stimulation of the perforant path. Potentiation of both population excitatory postsynaptic potential (EPSP) slope and population spike was studied at various times after conditioning out to 5 h. The results indicate that prenatal protein malnutrition has a differential effect on LTP. Although potentiation of the population spike was relatively unaffected, prenatal protein malnutrition did lead to a significant reduction in potentiation of the population EPSP. Several possibilities are proposed as to the cause of the differential effect.

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