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. 2018 Oct;12(5):919-926.
doi: 10.31616/asj.2018.12.5.919. Epub 2018 Sep 10.

Prognosis of Single Spinal Metastatic Tumors: Predictive Value of the Spinal Instability Neoplastic Score System for Spinal Adverse Events

Sam Yeol Chang  1 , Jae Hong Ha  1 , Sang Gyo Seo  2 , Bong-Soon Chang  1 , Choon-Ki Lee  1 , Hyoungmin Kim  1
Affiliations

Prognosis of Single Spinal Metastatic Tumors: Predictive Value of the Spinal Instability Neoplastic Score System for Spinal Adverse Events

Sam Yeol Chang et al. Asian Spine J. 2018 Oct.

Abstract

Study design: This was a retrospective cohort study.

Purpose: We evaluated the predictive value of the Spinal Instability Neoplastic Score (SINS) system for spinal adverse events (SAEs) in patients with single spinal metastatic tumor.

Overview of literature: The SINS system was developed to assess spinal instability in patients with single metastatic spinal tumor. However, the system's potential predictive value for SAEs has been partially studied.

Methods: This system was applied to a retrospective cohort of 78 patients with single spinal metastatic tumors. The patients underwent surgical treatment and were postoperatively followed up for at least 2 years or until death. The attribution of each score and total SINS to SAE (vertebral compression fracture [VCF] and spinal cord compression [SCC]) occurrence was assessed using the Cox proportional hazards model.

Results: SAEs occurred on average 7 months after diagnosis of spinal metastasis. The mean survival rate post diagnosis was 43 months. Multivariate analysis using the Cox proportional hazards model revealed that the pain (p =0.029) and spinal alignment (p =0.001) scores were significantly related to VCF occurrence, whereas the pain (p =0.008) and posterolateral involvement (p =0.009) scores were related to SCC occurrence.

Conclusions: Among the components of the SINS system, while pain and spinal alignment showed a significant association with VCF occurrence, pain and posterolateral involvement showed association with SCC occurrence.

Keywords: Compression fractures; Neoplasm metastasis; Spinal Instability Neoplastic Score; Spinal cord compression.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Survival function graph for spinal cord compression according to the pain score (A) and posterolateral component involvement (B).
Fig. 2.
Fig. 2.
Survival function graph for vertebral compression according to the pain score (A) and radiographic spinal alignment (B).
See this image and copyright information in PMC

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