doi: 10.1016/0165-4608(86)90189-5.
Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia
- PMID: 3021321
- DOI: 10.1016/0165-4608(86)90189-5
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Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia
Cancer Genet Cytogenet.
1986 Nov.
Abstract
The human genome contains two distinct loci with homology to the viral ets gene, the transforming sequence of the E26 avian erythroblastosis virus; these loci, Hu-ets-1, and Hu-ets-2, have been mapped to 11q23 and 21q22, respectively. Using in situ chromosomal hybridization, we have demonstrated that Hu-ets-2 is translocated to chromosome #8, the chromosome containing the critical or conserved junction, as a result of the t(8;21) (q22;q22) in acute myelogenous leukemia. Another protooncogene, c-mos, is also retained at the conserved junction, suggesting that one or both of these genes may play a role in the pathogenesis of acute myelogenous leukemia.
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