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. 1986 Nov;23(3):269-74.
doi: 10.1016/0165-4608(86)90189-5.

Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia

M M Le Beau, J D Rowley, N Sacchi, D K Watson, T S Papas, M O Diaz

Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia

M M Le Beau et al. Cancer Genet Cytogenet. 1986 Nov.

Abstract

The human genome contains two distinct loci with homology to the viral ets gene, the transforming sequence of the E26 avian erythroblastosis virus; these loci, Hu-ets-1, and Hu-ets-2, have been mapped to 11q23 and 21q22, respectively. Using in situ chromosomal hybridization, we have demonstrated that Hu-ets-2 is translocated to chromosome #8, the chromosome containing the critical or conserved junction, as a result of the t(8;21) (q22;q22) in acute myelogenous leukemia. Another protooncogene, c-mos, is also retained at the conserved junction, suggesting that one or both of these genes may play a role in the pathogenesis of acute myelogenous leukemia.

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