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Comment
. 2018 Oct;39(10):852-854.
doi: 10.1016/j.tips.2018.08.005. Epub 2018 Sep 10.

Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis

Finn J Hawkins  1 , Darrell N Kotton  2
Affiliations
Comment

Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis

Finn J Hawkins et al. Trends Pharmacol Sci. 2018 Oct.

Abstract

Two recent studies have identified novel airway cells termed pulmonary ionocytes that express higher levels of CFTR than other airway cells express. These findings raise new questions in the evolving debate about the physiological role of CFTR in lung epithelia and its importance in the pathogenesis of cystic fibrosis (CF).

Keywords: CFTR; airway; cystic fibrosis; ionocyte; lung.

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    Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. Montoro DT, et al. Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1. Nature. 2018. PMID: 30069044 Free PMC article.
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