New Evidence for Hypnozoite-Independent Plasmodium vivax Malarial Recurrences
- PMID: 30213708
- DOI: 10.1016/j.pt.2018.08.010
New Evidence for Hypnozoite-Independent Plasmodium vivax Malarial Recurrences
Abstract
Information provided in recent, related papers has wide-ranging implications concerning, inter alia, the transmission of malaria, drug treatment, and eradication of the disease. Additionally, the research results represent support for the idea that recurrences of Plasmodium vivax malaria can arise from both liver hypnozoites and extravascular merozoites in bone marrow.
Keywords: bone marrow; life cycle; liver; recrudescence; relapse; spleen.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy.Nat Commun. 2018 Apr 27;9(1):1689. doi: 10.1038/s41467-018-04108-9. Nat Commun. 2018. PMID: 29703959 Free PMC article.
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Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.mBio. 2018 May 8;9(3):e00625-18. doi: 10.1128/mBio.00625-18. mBio. 2018. PMID: 29739900 Free PMC article.
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Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow.Sci Adv. 2018 May 23;4(5):eaat3775. doi: 10.1126/sciadv.aat3775. eCollection 2018 May. Sci Adv. 2018. PMID: 29806032 Free PMC article.
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