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. 2018 Sep 12:10:69.
doi: 10.1186/s13098-018-0371-0. eCollection 2018.

Nerve conduction study of the association between glycemic variability and diabetes neuropathy

Miho Akaza  1 , Itaru Akaza  2 , Tadashi Kanouchi  3 , Tetsuo Sasano  4 , Yuki Sumi  1 , Takanori Yokota  5
Affiliations

Nerve conduction study of the association between glycemic variability and diabetes neuropathy

Miho Akaza et al. Diabetol Metab Syndr. .

Abstract

Background: It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN). We investigated the association between glycemic variability and DPN with type 1 or 2 diabetes.

Methods: Forty patients (23 males and 17 females; aged 34-79 years) underwent continuous glucose monitoring (CGM) and a nerve conduction study (NCS). Glycemic variability was estimated by mean amplitude of glycemic excursions (MAGE) in CGM. DPN was quantitatively evaluated by NCS in the median, tibial, sural and medial plantar nerves.

Results: MAGE had a significantly positive correlation with disease duration and low-density lipoprotein cholesterol level (r = 0.462, p = 0.003; and r = 0.40, p = 0.011, respectively), and a significantly negative correlation with BMI and medial plantar compound nerve action potential amplitude (r = - 0.39, p = 0.012; and r = - 0.32, p = 0.042, respectively). Multivariate linear regression analysis with adjustment for clinical background showed that MAGE (β = - 0.49, p= 0.007) was independently associated with a higher risk of medial plantar neuropathy.

Conclusions: Glycemic variability may be an independent risk factor for DPN.

Keywords: Continuous glucose monitoring; Diabetes peripheral neuropathy; Glycemic variability; Nerve conduction study.

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Figures

Fig. 1
Fig. 1
Univariate linear regression analysis of medial plantar CNAP amplitude and clinical parameters including age (a), disease duration (b), SBP (c), LDL (d), BMI (e), HbA1c (f), and MAGE (g). Medial plantar CNAP amplitude was shown to have a negative correlation with age, SBP, and MAGE
See this image and copyright information in PMC

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