Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jul 10;6(9):1718-1722.
doi: 10.1002/ccr3.1712. eCollection 2018 Sep.

Application of the modified Zajicek criteria to diagnose probable spinal cord neurosarcoidosis

Ceris Ifan Owen  1 , Farrah Jabeen  2 , Anupam Bhattacharjee  3
Affiliations
Case Reports

Application of the modified Zajicek criteria to diagnose probable spinal cord neurosarcoidosis

Ceris Ifan Owen et al. Clin Case Rep. .

Abstract

Neurosarcoidosis represents a significant diagnostic challenge, as clinical features overlap with other neuroinflammatory conditions, and biopsy of affected neuronal tissue is often high risk or not feasible. Here we highlight application of the modified Zajicek criteria to diagnose probable spinal neurosarcoidosis in the absence of histology from affected neuronal tissue.

Keywords: acute medicine; neurology; respiratory medicine; sarcoidosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
MR Imaging of Lumbar Spine. A, T2‐weighted sagittal images of the lumbar spine (no enhancement); multiple diffuse low signal nodular lesions involving the cauda equina. B, T1‐weighted postgadolinium coronal imaging of the lumbar spine; diffuse nodular enhancement of the cauda equina
Figure 2
Figure 2
FDG‐PET Imaging. A, Intense metabolic activity associated with pathological mediastinal and bihilar lymphadenopathy. B, Multifocal FDG avid liver lesions. C, Intense focal tracer uptake within the spinal canal compatible with nodular enhancing MR lesions
See this image and copyright information in PMC

References

    1. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Muller‐Quernheim J. Sarcoidosis. Lancet. 2014;383(9923):1155‐1167. - PubMed
    1. Ginat DT, Dhillon G, Almast J. Magnetic resonance imaging of neurosarcoidosis. J Clin Imaging Sci. 2011;1:15. - PMC - PubMed
    1. Marangoni S, Argentiero V, Tavolato B. Neurosarcoidosis. Clinical description of 7 cases with a proposal for a new diagnostic strategy. J Neurol. 2006;253(4):488‐495. - PubMed
    1. Tavee JO, Stern BJ. Neurosarcoidosis. Clin Chest Med. 2015;36(4):643‐656. - PubMed
    1. Zajicek JP, Scolding NJ, Foster O, et al. Central nervous system sarcoidosis–diagnosis and management. QJM. 1999;92(2):103‐117. - PubMed

Publication types

LinkOut - more resources