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Case Reports
. 2018 Sep 10:6:2050313X18795071.
doi: 10.1177/2050313X18795071. eCollection 2018.

Treatment of Darier's disease with oral magnesium: a case report

Heidi Oi-Yee Li  1 , Sophia Colantonio  1 , Nordau Kanigsberg  2
Affiliations
Case Reports

Treatment of Darier's disease with oral magnesium: a case report

Heidi Oi-Yee Li et al. SAGE Open Med Case Rep. .

Abstract

Darier's disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca2+-ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, including topical corticosteroids, antibiotics, antifungals and retinoids, often have limited efficacy. The present article reports the novel use of oral magnesium chloride supplementation (300 mg daily) in the treatment of Darier disease. After 5 years of limited improvement using conventional therapies, significant improvements in neck lesions were observed within 1 month of starting oral magnesium chloride. This suggests that oral magnesium chloride may be an effective therapeutic option for Darier disease, although further in vitro and clinical trials are necessary to evaluate its clinical efficacy.

Keywords: Darier’s disease; genodermatosis; therapeutics.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Right lateral neck plaque of a 15-year-old male with Darier’s disease (a) before (b) week 6 of treatment and (c) 1 month after a 4-month course of treatment with oral magnesium.
See this image and copyright information in PMC

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