Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun 24;8(3):e68763.
doi: 10.5812/aapm.68763. eCollection 2018 Jun.

Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

Fatemeh Javaherforooshzadeh  1 , Iren Amirpour  1 , Farahzad Janatmakan  1 , Mansour Soltanzadeh  1
Affiliations

Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

Fatemeh Javaherforooshzadeh et al. Anesth Pain Med. .

Abstract

Background: Surgery is one of the stressors that cause physiological and psychological stress. Anxiety and pain and their complications are very important in anesthesiology and many researches have been done to decrease or eliminate them. This training was done to compare the effect of melatonin and gabapentin on pain and anxiety during lumbar surgery.

Methods: This study was a double-blinded clinical trial conducted on 90 patients undergoing lumbar surgery with general anesthesia in Golestan Academic Hospital in 2017. Patients were randomly assigned into 3 groups: 30 patients received 6 mg melatonin, 30 patients received 600 mg gabapentin, and 30 patients were on placebo (control), 100 minutes preoperatively. All patients were given a fixed method of anesthesia. The pain intensity and patients' satisfaction from analgesia measured at 1, 2, 6, 12, and 24 h after surgery. The anxiety was measured 15 minutes before surgery and 1, 2, 6, 12, and 24 h after surgery.

Results: In our study, there was a significant difference between mean Visual Analog Score between melatonin and gabapentin groups in comparison to placebo (P = 0.02). The intensity of anxiety among the groups was lower in melatonin and gabapentin groups in comparison to placebo (P = 0.01).

Conclusions: The results show that pretreatment with melatonin or gabapentin decreases anxiety and pain in lumbar surgery.

Keywords: Anxiety; Discectomy; Gabapentin; Melatonin; Pain.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Consort Flow Diagram
See this image and copyright information in PMC

References

    1. Foggitt PS. Anxiety in cataract surgery: pilot study. J Cataract Refract Surg. 2001;27(10):1651–5. - PubMed
    1. Caumo W, Ferreira MBC. Perioperative anxiety: psychobiology and effects in postoperative recovery. Pain Clinic. 2003;15(2):87–101.
    1. Phipps WJ, Monahan F. D., Sands J, Marek JF, Neighbors M. Medical-surgical nursing: Health and illness perspectives. Louis: Mosby; 2003.
    1. Barker R, Kober A, Hoerauf K, Latzke D, Adel S, Kain ZN, et al. Out-of-hospital auricular acupressure in elder patients with hip fracture: a randomized double-blinded trial. Acad Emerg Med. 2006;13(1):19–23. doi: 10.1197/j.aem.2005.07.014. - DOI - PubMed
    1. Agarwal A, Ranjan R, Dhiraaj S, Lakra A, Kumar M, Singh U. Acupressure for prevention of pre-operative anxiety: a prospective, randomised, placebo controlled study. Anaesthesia. 2005;60(10):978–81. doi: 10.1111/j.1365-2044.2005.04332.x. - DOI - PubMed

LinkOut - more resources