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Review
. 2017 Jul 1:2:154-160.
doi: 10.1016/j.cnp.2017.06.001. eCollection 2017.

The role for ketogenic diets in epilepsy and status epilepticus in adults

Tanya J Williams  1 , Mackenzie C Cervenka  1
Affiliations
Review

The role for ketogenic diets in epilepsy and status epilepticus in adults

Tanya J Williams et al. Clin Neurophysiol Pract. .

Abstract

Ketogenic diet (KD) therapies are high fat, low carbohydrate diets designed to mimic a fasting state. Although studies demonstrate KD's success in reducing seizures stretching back nearly a century, the last 25 years have seen a resurgence in diet therapy for the management of drug-resistant epilepsy in children as well as adults. With ≥50% seizure reduction efficacy rates in adults of 22-55% for the classic KD and 12-67% for the modified Atkins diet, diet therapy may be in many instances comparable to a trial of an additional anti-epileptic medication and potentially with fewer side effects and other health benefits. Moreover, ketogenic diets offer promising new adjunctive strategies for the treatment of acute status epilepticus in the intensive care setting. Here, we review the efficacy and utility of ketogenic diets for the management of chronic epilepsy and refractory status epilepticus in adults and offer practical guidelines for diet implementation and maintenance.

Keywords: Drug-resistant epilepsy; Epilepsy; Ketogenic diet; Modified Atkins diet; Refractory status epilepticus.

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References

    1. Amer S., Shah P., Kommineni V. Refractory status epilepticus from NMDA receptor encephalitis successfully treated with an adjunctive ketogenic diet. Ann. Indian Acad. Neurol. 2015;18:256–257. - PMC - PubMed
    1. Barañano K.W., Hartman A.L. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr. Treat. Options Neurol. 2008;10:410–419. - PMC - PubMed
    1. Barborka C.J. Ketogenic diet treatment of epilepsy in adults. JAMA. 1928;9:73–78.
    1. Barborka C.J. Epilepsy in adults: results of treatment by ketogenic diet in one hundred cases. Arch. Neurol. Psychiatr. 1930;23:904–914.
    1. Bastible C. The ketogenic treatment of epilepsy. Irish J. Med. Sci. 1931;6:506–520.