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. 1977 Aug;12(2):77-9.
doi: 10.1111/j.1399-0004.1977.tb00905.x.

Alpha-I-antitrypsin (Pi) phenotypes in Lyon, France: departure from Hardy-Weinberg equilibrium

P Arnaud, J P Pandey, H H Fudenberg, C Chapuis-Cellier, P Vittoz, R Creyssel

Alpha-I-antitrypsin (Pi) phenotypes in Lyon, France: departure from Hardy-Weinberg equilibrium

P Arnaud et al. Clin Genet. 1977 Aug.

Abstract

The validity of the Hardy-Weinberg equilibrium for Pi phenotypes was tested in a population of 1,653 randomly selected, healthy blood donors in Lyon, France. A significant departure from the equilibrium was found, with an excess of FF and SS homozygotes and a deficiency of FM heterozygotes.

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