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Case Reports
. 2018 Sep;32(5):1768-1772.
doi: 10.1111/jvim.15236. Epub 2018 Sep 14.

Newborn foal with atypical myopathy

Radana Karlíková  1   2 , Jitka Široká  2   3 , Marek Mech  4 , David Friedecký  1   2   5 , Hana Janečková  2   5 , Lucie Mádrová  1   2 , Františka Hrdinová  6 , Zuzana Drábková  6 , Olga Dobešová  6 , Tomáš Adam  1   2   5 , Petr Jahn  6
Affiliations
Case Reports

Newborn foal with atypical myopathy

Radana Karlíková et al. J Vet Intern Med. 2018 Sep.

Abstract

The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal's dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a myopathy, elevated serum activity of creatine kinase, metabolomic analysis and the presence of methylenecyclopropyl acetyl carnitine (MCPA-carnitine) in the blood. At the time of delivery, the mare was grazing on a pasture near sycamore trees but was free of clinical signs of AM. Metabolomic analysis of the foal's blood revealed increased concentrations of acylcarnitines and MCPA-carnitine consistent with metabolic profiles of blood from AM affected horses. Two theories could explain this observation (a) hypoglycin A or its metabolites accumulated in the mare's placenta with consequent transfer to fetus or (b) these compounds were secreted into mare's milk.

Keywords: acylcarnitines; hypoglycin A; metabolomics; methylenecyclopropyl acetyl carnitine; multiple acyl-coenzyme A dehydrogenase deficiency.

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Figures

Figure 1
Figure 1
A, Principal component analysis score plot of horses with AM (green triangles), affected foal (red triangle), and controls (adult horses: blue squares; foals: pink squares); B, Boxplots of acylcarnitines in blood of horses with AM (green triangles), affected foal (red triangle) and controls (adult horses: blue squares; foals: pink squares)
See this image and copyright information in PMC

References

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