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Review
. 1986;37(8):789-98.
doi: 10.1016/0883-2889(86)90273-x.

Astatine-211: its possible applications in cancer therapy

I Brown
Review

Astatine-211: its possible applications in cancer therapy

I Brown. Int J Rad Appl Instrum A. 1986.

Abstract

The cyclotron-produced radiohalogen, 211At, is eminently suitable as a possible therapeutic radionuclide. It decays by the emission of 6.8 MeV mean energy alpha-particles, which from a radiobiological viewpoint are of near optimal therapeutic LET. This paper reviews developments in the possible application of [211At]astato-labelled molecules as potential anti-tumour agents. Additionally, radio-dosimetric evidence is presented, and its implications for human cancer therapy are discussed.

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