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. 2018 Sep 14;15(1):266.
doi: 10.1186/s12974-018-1299-x.

NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment

Lei Yin  1   2 , Fangping Bao  3 , Jing Wu  4 , Kuanyu Li  5
Affiliations

NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment

Lei Yin et al. J Neuroinflammation. .

Abstract

Wang Z et al. recently published a paper, titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment". The finding in this paper is consistent with our previous study on NLRP3-caspase-1 pathway. Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.

Keywords: Cognition; Isoflurane; MCC950; NLRP3; Pyroptosis.

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