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Review
. 2018 Sep 14;37(1):226.
doi: 10.1186/s13046-018-0901-5.

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Hongmei Zheng  1 , Yuting Zhan  1 , Sile Liu  1 , Junmi Lu  1 , Jiadi Luo  1 , Juan Feng  1 , Songqing Fan  2
Affiliations
Review

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Hongmei Zheng et al. J Exp Clin Cancer Res. .

Abstract

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, and it is one of the leading causes of cancer death in both men and women worldwide due to diagnosis in the advanced stage, rapid metastasis, and recurrence. At present, precision molecular targeted therapeutics directed toward NSCLC driven genes has made great progress and significantly improved the overall survival of patients with NSCLC, but can easily lead to acquired drug resistance. New methods are needed to develop real-time monitoring of drug efficacy and drug resistance, such as new molecular markers for more effective early detection and prediction of prognosis. Exosomes are nano-sized extracellular vesicles, containing proteins, nucleic acids and lipids, which are secreted by various cells, and they play an important role in the development of lung cancer by controlling a wide range of pathways. Tumor-derived exosomes are of great significance for guiding the targeted therapy of NSCLC and exosomes themselves can be a target for treatment. In this review, we describe the potential roles of tumor-derived exosomes and their clinical significance in NSCLC.

Keywords: Clinical implications; NSCLC; Targeted therapy; Tumor-derived exosomes.

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Competing interests

The authors declare they have no competing interests.

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Figures

Fig. 1
Fig. 1
The biology of exosomes. Exosomes are some vesicles ranged from 40 to 100 nm, which can be released by many cells and purified from many body fluids. Exosomes can transfer information to the receptor cells through fusion with the plasma membrane, endocytosis by phagocytic mechanism or receptor-ligand interaction with the cell
Fig. 2
Fig. 2
Roles of Tumor-derived exosomes in the NSCLC. Tumor-derived exosomes play a vital role in tumor growth and progression, invasion and metastasis, targeted drug resistance, and can also be used as biomarkers for early diagnosis, prediction of treatment response and prognosis
See this image and copyright information in PMC

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