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Randomized Controlled Trial
. 2018 Sep 14;8(1):13849.
doi: 10.1038/s41598-018-32285-6.

Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong

Ruth Suk-Mei Chan  1 , Wing-Hung Tam  2 , Ivan Chak-Hang Ho  3 , Macy Wai-Chi Kwan  3 , Liz Sin Li  3 , Mandy Man-Mei Sea  4 , Jean Woo  3
Affiliations
Randomized Controlled Trial

Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong

Ruth Suk-Mei Chan et al. Sci Rep. .

Abstract

Gestational diabetes mellitus (GDM) is of public health concern. This trial examined whether a clinically proven lifestyle modification program (LMP) in early pregnancy was superior to routine antenatal care in improving GDM, maternal and infant outcomes. Chinese pregnant women at risk of GDM (n = 220) were recruited at or before 12-week gestation and randomized to either a LMP group or a routine care control group. Eighty subjects completed a dietitian-led LMP including dietary and exercise components from early pregnancy till 24-week gestation. Data were compared with those of 86 control subjects. Twenty three (26.7%) control subjects and 20 (25.0%) LMP subjects developed GDM (p = 0.798). The proportion of infants born large for gestational age and macrosomia was similar between groups. The LMP group showed a lower proportion of excessive gestational weight gain (GWG). Subgroup analysis suggested that those with higher LMP adherence showed more desirable dietary composition and energy intake, and lower proportion of excessive GWG compared with the low LMP adherence group and the control group. The potential effect of LMP on GDM and other maternal and infant outcomes, in particular GWG, as well as barriers for making lifestyle changes warrant further investigations (ClinicalTrials.gov NCT02368600).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
ITT - intention to treat. PP – per protocol. LMP – lifestyle modification program.
See this image and copyright information in PMC

References

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