Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun:126:85-104.
doi: 10.1016/j.nbd.2018.09.011. Epub 2018 Sep 13.

Stem cell therapy for neurological disorders: A focus on aging

Hung Nguyen  1 , Sydney Zarriello  1 , Alexandreya Coats  1 , Cannon Nelson  1 , Chase Kingsbury  1 , Anna Gorsky  1 , Mira Rajani  1 , Elliot G Neal  1 , Cesar V Borlongan  2
Affiliations
Review

Stem cell therapy for neurological disorders: A focus on aging

Hung Nguyen et al. Neurobiol Dis. 2019 Jun.

Abstract

Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and the progression of major neurological disease states such as Parkinson's disease, Huntington's disease, stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. We raise important questions to guide future research and advance novel treatment options.

Keywords: Age-related brain disorders; Cell-therapy; Neurodegenerative diseases; Stroke; Traumatic brain injury.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:. The effect of aging on stem cell therapy in age-related disorders.
Stem cell therapy demonstrates a potentially neuroprotective effect on age related diseases listed in the illustration. However, aging could diminish the therapeutic effects of stem cells within these diseases, potentially leading to graft failure and other risks.
See this image and copyright information in PMC

References

    1. Abati E, Di Fonzo A, Corti S, 2018. In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells. J. Cell. Mol. Med 22, 2536–2546. - PMC - PubMed
    1. Acosta SA, Tajiri N, Hoover J, Kaneko Y, Borlongan CV, 2015. Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke. Stroke 46, 2616–27. - PMC - PubMed
    1. Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Sanberg PR, Sanchez-Ramos J, Song S, Kaneko Y, Borlongan CV, 2014. Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury. PLoS One 9, e90953. - PMC - PubMed
    1. Aksoy C, Kaya FA, Kuskonmaz BB, Uckan D, Severcan F, 2014. Structural investigation of donor age effect on human bone marrow mesenchymal stem cells: FTIR spectroscopy and imaging. Age (Dordr) 36, 9691. - PMC - PubMed
    1. Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK, 2013. GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol. Ther 138, 155–75. - PubMed

Publication types