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. 2018 Nov;41(11):765-767.
doi: 10.1016/j.tins.2018.08.012. Epub 2018 Sep 12.

New Roles for an Ancient Factor

Francis S Lee  1 , Barbara L Hempstead  2
Affiliations

New Roles for an Ancient Factor

Francis S Lee et al. Trends Neurosci. 2018 Nov.

Abstract

In 1996, Hyejin Kang and Erin Schuman, in search of new functions for the secreted growth factor brain-derived neurotrophic factor (BDNF), identified the protein synthesis requirement of BDNF in regulating synaptic plasticity. This landmark paper identified one of the first tractable pathways in the quest to dissect the complex process of synaptic remodeling and revealed the critical role for this neurotrophin in regulating long-term memory.

Keywords: BDNF; long-term potentiation.

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