doi: 10.1128/JVI.60.2.768-770.1986.
Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts
- PMID: 3022009
- PMCID: PMC288954
- DOI: 10.1128/JVI.60.2.768-770.1986
Item in Clipboard
Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts
J Virol.
1986 Nov.
Abstract
Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.
Similar articles
-
Truncated forms of the polyomavirus middle T antigen can substitute for the small T antigen in lytic infection.J Virol. 1986 Jan;57(1):367-70. doi: 10.1128/JVI.57.1.367-370.1986. J Virol. 1986. PMID: 3001358 Free PMC article.
-
Small and middle T antigens contribute to lytic and abortive polyomavirus infection.J Virol. 1985 Feb;53(2):579-86. doi: 10.1128/JVI.53.2.579-586.1985. J Virol. 1985. PMID: 2578576 Free PMC article.
-
Superinfection rescue of an integrated defective polyomavirus genome.J Virol. 1986 Jan;57(1):205-10. doi: 10.1128/JVI.57.1.205-210.1986. J Virol. 1986. PMID: 3001345 Free PMC article.
-
Recent progress in studies of polyomavirus tumour antigens.Exp Cell Res. 1985 Mar;157(1):1-7. doi: 10.1016/0014-4827(85)90146-6. Exp Cell Res. 1985. PMID: 2982625 Review.
-
Role of mouse polyomavirus late region in the control of viral DNA replication: a review.Biochimie. 1995;77(10):780-6. doi: 10.1016/0300-9084(96)88196-x. Biochimie. 1995. PMID: 8824775 Review.
Cited by
-
Transcriptional regulation of early-response genes during polyomavirus infection.J Virol. 1990 May;64(5):2193-201. doi: 10.1128/JVI.64.5.2193-2201.1990. J Virol. 1990. PMID: 1691311 Free PMC article.
-
Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.J Virol. 1993 Apr;67(4):1945-52. doi: 10.1128/JVI.67.4.1945-1952.1993. J Virol. 1993. PMID: 7680388 Free PMC article.
-
Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1292-6. doi: 10.1073/pnas.92.5.1292. Proc Natl Acad Sci U S A. 1995. PMID: 7877970 Free PMC article.
-
Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.J Virol. 2001 Mar;75(5):2253-61. doi: 10.1128/JVI.75.5.2253-2261.2001. J Virol. 2001. PMID: 11160729 Free PMC article.
-
Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.J Virol. 2011 Oct;85(20):10649-58. doi: 10.1128/JVI.05034-11. Epub 2011 Aug 10. J Virol. 2011. PMID: 21835797 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
