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. 1986 Nov;60(2):768-70.
doi: 10.1128/JVI.60.2.768-770.1986.

Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts

H Berger, E Wintersberger

Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts

H Berger et al. J Virol. 1986 Nov.

Abstract

Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.

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References

    1. Nature. 1981 Aug 13;292(5824):595-600 - PubMed
    1. Nature. 1982 Dec 23;300(5894):713-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4354-8 - PubMed
    1. EMBO J. 1983;2(12):2095-101 - PubMed
    1. J Mol Biol. 1967 Jun 14;26(2):365-9 - PubMed

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