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. 1977 Jul;7(7):443-7.
doi: 10.1002/eji.1830070708.

H-2 gene complementation in cytotoxic T cell responses of female against male cells

H-2 gene complementation in cytotoxic T cell responses of female against male cells

H von Boehmer et al. Eur J Immunol. 1977 Jul.

Abstract

H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level of antigen-presenting cells (stimulators, targets), the other must be expressed in the responding T cell population.

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