H-2 gene complementation in cytotoxic T cell responses of female against male cells
- PMID: 302210
- DOI: 10.1002/eji.1830070708
H-2 gene complementation in cytotoxic T cell responses of female against male cells
Abstract
H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level of antigen-presenting cells (stimulators, targets), the other must be expressed in the responding T cell population.
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