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Comparative Study
. 1986 Mar;6(3):842-8.
doi: 10.1128/mcb.6.3.842-848.1986.

Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene

J D McDonald, F K Lin, E Goldwasser
Comparative Study

Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene

J D McDonald et al. Mol Cell Biol. 1986 Mar.

Abstract

The gene for mouse erythropoietin was cloned and sequenced. We present here a preliminary analysis of the overall genomic organization of the coding portions and the two flanking regions of the gene. This is the third mammalian erythropoietin for which the sequence is available, but it represents the first from a nonprimate species. We investigated the evolutionary divergence of sequence and structure of the three erythropoietins and identified specific regions of the molecules that are apparently under various degrees, and perhaps different types, of functional constraint.

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References

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