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Review
. 2018 Oct;18(10):773-784.
doi: 10.1080/14737175.2018.1523721. Epub 2018 Sep 24.

Deep brain stimulation for childhood dystonia: current evidence and emerging practice

Affiliations
Review

Deep brain stimulation for childhood dystonia: current evidence and emerging practice

Lior M Elkaim et al. Expert Rev Neurother. 2018 Oct.

Abstract

Dystonia, one of the most common childhood movement disorders, is often medically refractory and can lead to profound impacts on the child and their caretakers' quality of life. Limited efficacy of pharmacological treatments has fueled enthusiasm for innovative neurosurgical approaches, notably deep brain stimulation (DBS) as a treatment for refractory dystonia. Areas covered: DBS is increasingly applied to successfully treat childhood dystonia. While generally safe and effective, results vary widely depending on underlying dystonia etiology. The current work synthesizes and highlights advances in research pertaining to the use of DBS for childhood dystonia. The efficacy of DBS for children and youth with dystonia is discussed, with analysis divided among etiological subtypes. The role of DBS as a lifesaving treatment for status dystonicus is also reviewed. Expert commentary: When carefully selected, certain children and youth with dystonia experience significant symptomatic improvement after DBS. Beyond dystonic symptoms, DBS can improve quality of life and reduce caretaker burden.

Keywords: DBS; childhood dystonia; deep brain stimulation; pediatric dystonia; status dystonicus.

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