Initial Ablation Ratio: Quantitative Value Predicting the Therapeutic Success of Thyroid Radiofrequency Ablation

Abstract

Background: The aims of this study were to determine a quantitative index, the initial ablation ratio (IAR), representing the amount of ablation, to predict therapeutic success and to evaluate the correlation between the IAR and volume reduction ratio (VRR).

Methods: Among the patients who underwent radiofrequency ablation (RFA) for the treatment of benign thyroid nodules at the Withsim Clinic between April 2008 and December 2016, 130 patients with 134 nodules were included. The relationship between the IAR and VRR was analyzed at six months, 12 months, and the final follow-up. The relationship between the IAR and final VRR was also analyzed according to the initial nodule volumes.

Results: The mean VRR was 78.7 ± 17.5% (range 23.3-100%) at a mean follow-up period of 22.6 ± 20.1 months (range 3-93 months). The mean IAR was 90.0 ± 11.6% (range 39.1-100%). The correlation coefficient between the IAR and final VRR was 0.65, which indicates a positive correlation (p < 0.001). When the IAR exceeded 70%, it tended to achieve 50% VRR in most cases.

Conclusions: The IAR is a quantitative indicator of how well the RFA procedures are performed, and it is highly correlated with the VRR. If the IAR is >70%, VRR of >50% may be expected after RFA.

Keywords: benign thyroid nodule; initial ablation ratio; radiofrequency ablation; therapeutic success; thermal ablation.