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Clinical Trial
. 2018 Sep 18;13(9):e0200117.
doi: 10.1371/journal.pone.0200117. eCollection 2018.

Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 - 2017)

Olga Kurskaya  1 , Tatyana Ryabichenko  2 , Natalya Leonova  3 , Weifeng Shi  4 , Hongtao Bi  5 , Kirill Sharshov  1 , Eugenia Kazachkova  1 , Ivan Sobolev  1 , Elena Prokopyeva  1 , Tatiana Kartseva  2 , Alexander Alekseev  1 , Alexander Shestopalov  1
Affiliations
Clinical Trial

Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 - 2017)

Olga Kurskaya et al. PLoS One. .

Abstract

Background: Acute respiratory infections (ARIs) cause a considerable morbidity and mortality worldwide especially in children. However, there are few studies of the etiological structure of ARIs in Russia. In this work, we analyzed the etiology of ARIs in children (0-15 years old) admitted to Novosibirsk Children's Municipal Clinical Hospital in 2013-2017.

Methods: We tested nasal and throat swabs of 1560 children with upper or lower respiratory infection for main respiratory viruses (influenza viruses A and B, parainfluenza virus types 1-4, respiratory syncytial virus, metapneumovirus, four human coronaviruses, rhinovirus, adenovirus and bocavirus) using a RT-PCR Kit.

Results: We detected 1128 (72.3%) samples were positive for at least one virus. The most frequently detected pathogens were respiratory syncytial virus (358/1560, 23.0%), influenza virus (344/1560, 22.1%), and rhinovirus (235/1560, 15.1%). Viral co-infections were found in 163 out of the 1128 (14.5%) positive samples. We detected significant decrease of the respiratory syncytial virus-infection incidence in children with increasing age, while the reverse relationship was observed for influenza viruses.

Conclusions: We evaluated the distribution of respiratory viruses in children with ARIs and showed the prevalence of respiratory syncytial virus and influenza virus in the etiological structure of infections. This study is important for the improvement and optimization of diagnostic tactics, control and prevention of the respiratory viral infections.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Viral co-infection rate in different age groups.
Fig 2
Fig 2. Detection rates of viral pathogens in single and co-infections in children with ARIs (2013–2017).
Fig 3
Fig 3. The distribution of respiratory viruses in different age groups.
Fig 4
Fig 4. Monthly distribution of HRSV, HRV and IFV.
Fig 5
Fig 5
Distribution of influenza A and B viruses in 2013–2017. a) 2013–2014 epidemic season. b) 2014–2015 epidemic season. c) 2015–2016 epidemic season. d) 2016–2017 epidemic season.
See this image and copyright information in PMC

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